Early identification and diagnosis of sepsis and septic shock is vitally important; despite appropriate management, mortality and morbidity rates remain high. For this reason, many biomarkers and screening systems have been investigated in accordance with the precision medicine concept. A narrative review was conducted to assess the role of mid-regional pro-adrenomedullin (MR-proADM) as a biomarker for sepsis and septic shock. Relevant studies were collected via an electronic PubMed, Web of Science, and The Cochrane Library search. The review focused on both diagnosis and prognosis in patients with sepsis and septic shock and specifically in subpopulations of patients with sepsis and septic shock with burns or malignant tumors. No exclusion criteria regarding age, sex, intensive care unit admission, follow-up duration, or co morbidities were used so as to maximize sensitivity and due to lack of randomized controlled trials, opinion paper and reviews were also included in this review. A total of 22 studies, one opinion paper, and one review paper were investigated. MR-proADM levels were found to be useful in assessing patients’ initial evolution and become even more useful during follow-up with increased area under curve values in the mortality prognosis by exceeding values of 0.8 in the data shown in several studies. These results also improve along with other biomarkers or severity scores and especially correlate with the organ failure degree. The results of this study indicate that MR-proADM is a good biomarker for the diagnosis and prognosis of sepsis and septic shock patients as well as for organ failure. Although several publications have discussed its role as a biomarker for pneumonia, its value as a biomarker for sepsis and septic shock should now be assessed in randomized controlled trials and more collaborative prospective studies with larger patient samples. Full article Advertising / Partnership © 2018 Plymouth Rock Assurance. All Rights Reserved. Career resources Supplier Diversity Program Manage Accounts If you’re looking for a one-stop shop for insurance, and you prefer having an agent nearby in a bricks-and-mortar office Products & programs photo credit Full-Mouth X-Ray Frequency Industry Events CBSNews.com The Fraud Division investigates suspected fraud committed by consumers or organized criminal elements perpetrated against insurance companies. Voices of Hope Risk Management Tools Emollients for Psoriasis Subscribe + Save! Skip to Brown menu Locate a "Lost" Life Insurance Policy "Who you are" is a pretty broad way to talk about the kind of risk you represent to an insurance company. Every company takes different factors into consideration, including the below: Arnold Jonas is another childhood friend of mine. Blond, ruddy-faced, and sporting a paunch at fifty-two, he has rarely had a nine-to-five job and isn’t looking for one. 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The company selling the plan contracts with a network of dentists.  Contracted dentists agree to discount their dental fees.  Patients pay all the costs of treatment at the contracted rate determined by the plan and there are no dental claim forms to file.  Originally these plans were sold to individuals; however, more and more employers are purchasing these types of plans as the dental plan for the company’s employees. In the community NPR Shop SR22 Learning Center Like most insurance policies/benefit programs, insurance policies/benefit programs offered by Metropolitan Life Insurance Company (MetLife) and its affiliates contain certain exclusions, exceptions, reductions, limitations, waiting periods and terms for keeping them in force.  Please contact MetLife or your plan administrator for complete details. 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