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Medicine has always been characterized by a tension between the particular and the general. A clinician is obligated to treat the individual in front of her, yet she accomplishes this task by applying generalized knowledge that describes an abstract average but not necessarily a specific person. Efforts to systematize this process of moving between the particular and the general have led to the development of randomized controlled trials and large observational studies. Inclusion of tens of thousands of people in such studies, it is argued, will enhance the applicability of the data to more individual circumstances. Yet, as genetic sequencing data have become more widely obtained and used, there has been an increased focus on what has been broadly termed “precision medicine”, a highly individualized approach to therapeutics. Moreover, advances in statistical methods have enabled researchers to use N-of-1 study data—traditionally considered too individualized to be broadly applicable—in new ways. This paper contextualizes these apparently modern debates with reference to historical arguments about methods of disease diagnosis and treatment, and earlier physicians’ concerns about the tension between the particular and the general that is intrinsic to medical practice. Full article
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peace of mind away from home With our dental discount program, you can choose from more than 131,000 available dental practices nationwide1 and make an appointment. After you see the dentist, show your discount card and you'll get instant savings – 15 percent to 50 percent off the cost of most services.* (Not available in Montana or Vermont.)
The yearly maximum is the most money that the dental insurance plan will pay within one full year. The yearly maximum will automatically renew every year. If you have unused benefits, these will not roll over. Most dental insurance companies allow an average yearly maximum of $1,000.
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Shop Medicare How to work with an agent or broker Lyme carditis (LC) is a manifestation of the early disseminated stage of Lyme disease and often presents as high-degree atrioventricular (AV) block. High-degree AV block in LC can be treated with antibiotics, usually resolving with a highly favorable prognosis, thus preventing the unnecessary
2 This APY was calculated using the Introductory Rate for 5.5 months, which is based on the average start date of an Introductory Rate plus 5 statement cycles, and the Standard Rate with a balance tier of $50,000-$999,999 for 6.5 months. Your combined Introductory and Standard Rate (Your APY) may vary depending on your Introductory Rate start date and your account balance.
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